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Unlike many peptides that are synthesized and secreted by endocrine glands, MOTS-c originates directly from the mitochondria, highlighting its intimate connection to cellular energy processes

In practice, the combination could create conflicting signals: GLP-1 suppressing appetite while GH promotes it, potentially worsening nausea or creating unpredictable eating patterns

And ironically, many of them end up having to slow down or pause treatment to recover, losing more time than if they had followed the schedule in the first place

In looking at clinical trial results, Mounjaro for type 2 diabetes had a greater effect on A1c and weight loss than Ozempic